1.
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 948-954, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-749256
ABSTRACT
OBJECTIVE@#To study genetic polymorphism of XRCC1 Arg399Gln and the laryngeal cancer risk.@*METHOD@#A case-control study was performed on 60 patients with laryngeal squamous cell carcinoma and 120 random healthy control group. The two groups were matched by sex and age. Multiplex SNaPshot technic was used to explore polymorphism of DNA repair gene XRCC1 Arg399Gln in distribution of patient with laryngeal squamous cell carcinoma and normal control.@*RESULT@#The frequency of XRCC1c. 399Arg/Gln+Gln/Gln genotypes in the case group was higher than that in the control group (P Gln might lead to a increased risk of laryngeal cancer.